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Anne Le Selected Research

Glutamine (L-Glutamine)

11/2022Metabolic reservoir cycles in cancer.
1/2021Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment.
1/2021Metabolic Intersection of Cancer and Cardiovascular Diseases: Opportunities for Cancer Therapy.
1/2021Glutamine Metabolism in Cancer.
1/2021Targeting Metabolic Cross Talk Between Cancer Cells and Cancer-Associated Fibroblasts.
1/2021Bridging the Metabolic Parallels Between Neurological Diseases and Cancer.
10/2020Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers.
11/2019Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer.
1/2018Glutamine Metabolism in Cancer.
1/2018Targeting Metabolic Cross Talk between Cancer Cells and Cancer-Associated Fibroblasts.
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Anne Le Research Topics

Disease

54Neoplasms (Cancer)
02/2024 - 11/2009
7Carcinogenesis
02/2024 - 11/2009
6Frailty
03/2024 - 01/2020
6Breast Neoplasms (Breast Cancer)
02/2024 - 12/2011
6Hypoxia (Hypoxemia)
01/2023 - 11/2009
6Pancreatic Neoplasms (Pancreatic Cancer)
01/2023 - 08/2012
5Inflammation (Inflammations)
03/2024 - 01/2020
5Lymphoma (Lymphomas)
11/2021 - 02/2010
2Pulmonary Arterial Hypertension
01/2024 - 11/2019
2Mitochondrial Diseases (Mitochondrial Disease)
10/2023 - 01/2021
2Glioblastoma (Glioblastoma Multiforme)
09/2023 - 09/2016
2Chronic Obstructive Pulmonary Disease (COPD)
04/2023 - 09/2009
2Non-Hodgkin Lymphoma (Lymphosarcoma)
01/2021 - 01/2018
1renal Oncocytoma
04/2024
1Prostatic Neoplasms (Prostate Cancer)
02/2024
1Atopic Dermatitis (Atopic Eczema)
01/2024
1Pulmonary Hypertension
01/2023
1Hyperkalemia
12/2022
1Hypotension (Low Blood Pressure)
12/2022
1Fatigue
12/2022
1Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
03/2022
1Glomerulonephritis
03/2022
1Wounds and Injuries (Trauma)
11/2021
1Hyperglycemia
01/2021
1Cardiovascular Diseases (Cardiovascular Disease)
01/2021
1Triple Negative Breast Neoplasms
01/2021
1Barth Syndrome
01/2021
1Hyperinsulinism (Hyperinsulinemia)
01/2021
1Type 2 Diabetes Mellitus (MODY)
01/2021

Drug/Important Bio-Agent (IBA)

18Glutamine (L-Glutamine)FDA Link
11/2022 - 11/2009
13Glucose (Dextrose)FDA LinkGeneric
01/2023 - 11/2009
11Lactic Acid (Lactate)FDA LinkGeneric
11/2021 - 11/2009
9GlutaminaseIBA
01/2021 - 01/2012
8EnzymesIBA
09/2023 - 06/2012
8Glutamic Acid (Glutamate)FDA Link
12/2022 - 06/2015
5LipidsIBA
02/2024 - 03/2011
4Fatty Acids (Saturated Fatty Acids)IBA
01/2024 - 11/2009
4Proteins (Proteins, Gene)FDA Link
01/2023 - 08/2014
4isospaglumic acid (NAAGA)IBA
12/2022 - 01/2019
3Biomarkers (Surrogate Marker)IBA
04/2024 - 08/2015
3Interleukin-6 (Interleukin 6)IBA
10/2023 - 01/2020
3IsotopesIBA
11/2021 - 01/2012
3Phospholipids (Phosphatides)FDA LinkGeneric
01/2021 - 01/2018
3Oxygen (Dioxygen)IBA
01/2021 - 11/2009
3Glutamate Carboxypeptidase II (N-Acetylaspartylglutamate Peptidase)IBA
01/2021 - 01/2019
3Lactate Dehydrogenase 5IBA
08/2015 - 02/2010
2NAD (NADH)IBA
04/2024 - 02/2010
2KynurenineIBA
03/2024 - 01/2020
2CalciumIBA
03/2024 - 11/2019
2Triglycerides (Triacylglycerol)IBA
02/2024 - 11/2022
2CytokinesIBA
01/2024 - 01/2021
2Amino AcidsFDA Link
01/2023 - 01/2021
2Neurotransmitter Agents (Neurotransmitter)IBA
12/2022 - 01/2019
2GlycogenIBA
11/2022 - 01/2016
2gamma-Aminobutyric Acid (GABA)IBA
11/2021 - 01/2021
2Ketone BodiesIBA
01/2021 - 01/2018
2Hormones (Hormone)IBA
01/2021 - 01/2018
2Nonesterified Fatty Acids (NEFA)IBA
01/2021 - 01/2018
2Reactive Oxygen Species (Oxygen Radicals)IBA
10/2020 - 11/2019
2CB-839IBA
10/2020 - 05/2016
2Transcription Factors (Transcription Factor)IBA
06/2012 - 11/2009
2p38 Mitogen-Activated Protein KinasesIBA
01/2009 - 10/2008
1Tryptophan (L-Tryptophan)FDA Link
04/2024
1Diacylglycerol O-AcyltransferaseIBA
02/2024
1Immunoglobulin A (IgA)IBA
01/2024
1long-chain-fatty-acid-CoA ligaseIBA
09/2023
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
04/2023
1Dinoprostone (PGE2)FDA Link
04/2023
1HexosaminesIBA
01/2023
1Uridine Diphosphate (UDP)IBA
01/2023
1Uridine Diphosphate N-AcetylglucosamineIBA
01/2023
1RNA (Ribonucleic Acid)IBA
01/2023
1Losartan (Cozaar)FDA LinkGeneric
12/2022
12- butyl- 4- chloro- 1- ((2'- (1H- tetrazol- 5- yl)(1,1'- biphenyl)- 4- yl)methyl)- 1H- imidazole- 5- carboxaldehydeIBA
12/2022
1PPAR gammaIBA
12/2022
1losartan carboxylic acidIBA
12/2022
1Antihypertensive Agents (Antihypertensives)IBA
12/2022
1Aminobutyrates (Aminobutyric Acid)IBA
12/2022
1Phosphocreatine (Neoton)IBA
11/2022
1Antineutrophil Cytoplasmic Antibodies (ANCA)IBA
03/2022
1HydrogelsIBA
11/2021
1Valsartan (Vals)FDA Link
11/2021
1CarbonIBA
11/2021
1Peptides (Polypeptides)IBA
11/2021
1Succinic Acid (Succinate)IBA
11/2021
1Peptide Hydrolases (Proteases)FDA Link
01/2021
1Drug CombinationsIBA
01/2021
1Cardiolipins (Cardiolipin)IBA
01/2021
1AcidsIBA
01/2021
1Immune Checkpoint InhibitorsIBA
01/2021
1PresenilinsIBA
01/2021
1Chelating AgentsIBA
01/2021
1CopperIBA
01/2021
1AntioxidantsIBA
10/2020
1PlatinumIBA
10/2020
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
10/2020

Therapy/Procedure

36Therapeutics
02/2024 - 01/2009
5Drug Therapy (Chemotherapy)
02/2024 - 01/2018
3Radiotherapy
01/2023 - 01/2018
1Immunotherapy
01/2021